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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4B
All Species:
4.55
Human Site:
S434
Identified Species:
16.67
UniProt:
P23588
Number Species:
6
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23588
NP_001408.2
611
69151
S434
T
G
T
S
T
T
S
S
R
N
A
R
R
R
E
Chimpanzee
Pan troglodytes
XP_001142097
610
69033
S434
T
G
T
S
T
T
S
S
R
N
A
R
R
R
E
Rhesus Macaque
Macaca mulatta
XP_001101380
607
68582
G430
T
G
T
S
A
T
S
G
R
N
A
R
R
R
E
Dog
Lupus familis
XP_534793
612
69170
G434
T
G
T
S
A
T
T
G
R
N
A
R
R
R
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BGD9
611
68821
G434
T
G
A
S
A
T
S
G
R
N
T
R
R
R
E
Rat
Rattus norvegicus
Q5XI72
248
27306
D90
G
F
C
Y
V
E
F
D
E
V
D
S
L
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393068
502
57369
G344
A
S
S
T
N
I
F
G
A
A
K
P
V
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98
96
N.A.
94.2
20.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
30.9
N.A.
N.A.
Protein Similarity:
100
99.8
98.5
97.7
N.A.
96.5
28.1
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
45.3
N.A.
N.A.
P-Site Identity:
100
100
86.6
80
N.A.
73.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
100
100
86.6
86.6
N.A.
73.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
15
0
43
0
0
0
15
15
58
0
0
0
0
% A
% Cys:
0
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
15
0
0
15
0
0
15
0
% D
% Glu:
0
0
0
0
0
15
0
0
15
0
0
0
0
0
86
% E
% Phe:
0
15
0
0
0
0
29
0
0
0
0
0
0
0
0
% F
% Gly:
15
72
0
0
0
0
0
58
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
15
0
0
15
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
15
0
0
0
0
72
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
72
0
0
72
72
72
0
% R
% Ser:
0
15
15
72
0
0
58
29
0
0
0
15
0
0
0
% S
% Thr:
72
0
58
15
29
72
15
0
0
0
15
0
0
0
15
% T
% Val:
0
0
0
0
15
0
0
0
0
15
0
0
15
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
15
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _